Science Highlights

The one-armed antibody, onartuzumab (pink) binds to the receptor tyrosine kinase, MET (green and blue) found on the surface of cells preventing the binding of hepatocyte growth factor (HGF) (red) disrupting the development and growth of tumors.

Biomolecular Structure Studies Advance an Antibody Approach to Cancer Therapy

Crystal structures obtained at the Advanced Light Source helped inform Genentech about the binding mechanism of a unique antibody that targets multiple cancer types. Read More »

Substituting Co into d-MoN gave enhanced activity which approaches that of Pt metal, and which is competitive with that of the best known non-noble metal alternatives.

Neutrons Reveal New Electrocatalyst Family for Producing Hydrogen Fuel

New catalyst material provides potential for cheaper renewable hydrogen production. Read More »

Scanning electron microscope image of 2D arrays of channels created in a silicon sheet taking advantage of novel interface interactions with the soft substrate.

Chemistry and Strain Allow New Microfabrication

Discovery of a new bonding mechanism has enabled the facile fabrication of arrays of semiconductor microstructures. Read More »

Copper (Cu) nanorods grown using physical vapor deposition.

Downsizing Has Its Rewards

New Theory has Guided Experiments for Making the Smallest Possible Metal Rods Useful as Air-tight Sealants. Read More »

Front view of metal organic framework (MOF-74), showing the almost perfectly one-dimensional chains of transition metal magnets (green sections of structure).

When Metal Organic Frameworks Turn into One-Dimensional Magnets

Simulations and experiments reveal one-dimensional nano-size magnets are formed in a common porous material. Read More »

Laser induced photodetachment is used to turn a stable F¯(H2O) molecule into FH2O to study the “half reaction” processes experimentally and theoretically.

A View from the Middle for Chemical Reactions

Studying the photodetachment of a stable anion provides an experimental-theoretical benchmark of the chemical dynamics. Read More »

Wide-field fluorescence images (upper) acquired simultaneously in two orthogonal polarizations (double-ended arrows) depicting the 1D diffusional motions of rod-shaped single molecules confined within surfactant-templated mesoporous silica (bottom scheme).

Wobbling Molecules Probe Wiggle Room in Nanochannels

Single-molecule wobbling measurements help to elucidate molecular confinement within cylindrical nanopores. Read More »

Representative structures of the fluoroprotactinates synthesized and their structures determined using single crystal X-ray crystallography.

At an Elemental Crossroad: Investigating the Chemistry of Protactinium

Studies of protactinium aim to understand its chemistry and its unique electronic properties in the actinide elements. Read More »

AFM micrograph of the muscovite (001) basal plane showing PuO2 nanoparticles after overnight exposure to 2 mM Pu(III) in 100 mM NaCl at pH 2.6 (image range: 200 nm×200 nm).

Surface-Mediated Formation of Plutonium Nanoparticles

Researchers observe metal-trapping on mineral surfaces. Read More »

Changes in primary DNA sequence (a) and three-dimensional structure (b) upon directed evolution of the noncatalytic protein hRXRα to the ligase enzyme 10C.

Watching the Evolution of a Protein’s Function

Study reveals structural changes leading to catalytic activity. Read More »