IRB7 is the Huron Click Commerce-based software used by DOE’s Central IRBs and a number of the DOE site IRBs for processing of IRB applications. PIs submit applications for IRB review via this system, and IRBs can review the applications using this system. Prior to filing applications for IRB review, PIs should contact their IRB Administrator directly for guidance on how to submit to this system. Once PIs have their user names and temporary passwords, they should log onto IRB7 by using the following link. It is helpful to look at the DOE Library (accessible on the left side of the screen), which has an investigator manual (HRP-103) as well as a study submission guide (HRP-109), a protocol template (HRP-503), a consent template (HRP-502), and many other useful tools for researchers and IRB members.