12.14.16

How to Convince Molecules to Self-Assemble into Precise Hollow Nanotubes

Scientists reveal another design principle for building nanostructures in soft matter, valuable for batteries, water purification, and more.

Click to enlarge photo. Enlarge Photo

Precision meets nano-construction. Cryo-electron microscopy images (left) show side and end views of a tiny “nanotube,” only 9 nanometers (nm) in diameter and tens of nanometers long. The tubes formed spontaneously when scientists dissolved specially designed molecules called peptoids (human-made stand-ins for a small protein) in water. The molecular model of the tube (right) shows the arrangement of the water-repelling (orange) and water-attracting (blue) parts of the molecules. Scientists believe the formation of this molecular arrangement has a dominant role in the controllable self-assembly of tiny tubes of uniform diameter at the nanoscale.

The Science

Uniform tiny tubes could change devices as diverse as cell phone batteries and water purifiers. The challenge is making the tubes the same. Scientists discovered a family of nature-inspired synthetic materials; when placed in water, the material spontaneously assembles into millions of long, hollow tubes. Detailed images showed that the resulting nanotubes could be tuned to all have the same diameter. The diameter can be as small as 5 to 10 nanometers. In comparison, a cold virus is about 30 nanometers in diameter.

The Impact

The team rewrote how certain molecules can form. They challenged well-established paradigms by creating open structures with exposed water-repelling and -attracting sections in water. This discovery is scalable. It can produce millions of tubes. These tubes can transport water-fearing molecules and ions for applications including water purification, rechargeable batteries, and cancer-fighting drug delivery.

Summary

The self-assembly of complex molecules containing water-attracting (hydrophilic) and water-repelling (hydrophobic) segments in water is important across many scientific disciplines. Surfactants are surface-active agents widely used in the chemical industry to control the interface between liquids or a solid and a liquid. Surfactants aggregate to give either spherical or cylindrical molecular structures with collapsed hydrophobic cores and hydrophilic outer surfaces when exposed to water. Similarly, proteins fold in three-dimensional structures with hydrophobic cores in the interior and hydrophilic groups in the exterior. In contrast, the molecular peptoid structures, a nature-inspired synthetic material, synthesized in this research at Lawrence Berkeley National Laboratory consist of hollow rings stacked to produce a tube. The key to verifying the formation of nanotubes is cryo-electron microscopy which imaged 50 of the nanotubes showing the diameter of each tube is relatively uniform along its length, as well as from tube to tube. This work suggests that flexible, low–molecular-weight sequence-defined polymers can serve as molecular tile units that can assemble into precision supramolecular architectures. How exactly these nanotubes form has yet to be determined. However, this latest research sheds light on their structure and hints at a new design principle for building nanotubes and other complex nanostructures. This kind of precision manufacturing is needed to create the nanotechnologies of tomorrow.

Contact

Nitash P. Balsara
Materials Sciences Division, Lawrence Berkeley National Laboratory
nbalsara@lbl.gov (510) 643-5037

Ron Zuckermann
Molecular Foundry, Lawrence Berkeley National Laboratory
rnzuckermann@lbl.gov; (510) 486-7091

Funding

Research supported by the U.S. Department of Energy, Office of Science, Basic Energy Sciences, including use of the Molecular Foundry and the Advanced Light Source, Office of Science national user facilities. Other support was from the Norwegian Research Council, under the SYNKNOYT Program (RL), a travel grant from the Peder Sather Center for Advanced Study, National Institutes of Health (cryo-electron microscopy facilities), and the European Synchrotron Radiation Facility (bioSAXS).

Publications

J. Sun, X. Jiang, R. Lund, K.H. Downing, N.P. Balsara, and R.N. Zuckermann, “Self-assembly of crystalline nanotubes from monodisperse amphiphilic diblock copolypeptoid tiles.” Proceedings of the National Academy of Sciences of the United States of America 113(15), 3954-3959 (2016). [DOI: 10.1073/pnas.1517169113]

Related Links

Lawrence Berkeley National Laboratory news release: Nature-Inspired Nanotubes that Assemble Themselves, with PrecisionExternal link

Chemical & Engineering News: Polypeptoid Self-Assembles into NanotubesExternal link

Highlight Categories

Program: BES, MSE

Performer/Facility: SC User Facilities, BES User Facilities, ALS, Foundry

Additional: Collaborations, Non-DOE Interagency Collaboration, International Collaboration

Last modified: 12/14/2016 6:04:53 PM